I hope you have seen it on TV. It was masterfully constructed, masterfully delivered. To quote Obungle: "it was the one we have been waiting for." A Republican with guts, that is.
The Country agreed with it (about 71% or so) which is a big setback for the Establishment. I will not go through the highlights of it, figuring you have heard it elsewhere. Instead of that, I will point out a couple of interesting aspects.
The Media follow the lessons learned from driving Nixon from office, so, the Media tried to lessen Trump's support by "leaking" that Trump was going to praise Obamacare and propose amnesty for the illegals waiting to be registered as democrats. It did not happen. Trump shored up the GOP on repealing Obamacare and fleshed out his programs. Including immigration.
Notable was the Media reaction to the speech. Even some in the Leftist Media admitted that it was a very good speech. And they all mimicked Chris Matthews that "Trump became President" with that speech. Which led Rush Limbaugh to note that the Liberals did not listen to Trump during the campaign, but simply heard the Media's characterization that Trump was a buffoon. So, they were surprised when confronted by a Trump who was every inch a President in command of his ideas. The problem was that even Chris Matthews (who interviewed Trump) approached the Donald on the basis of "gottya" i.e trying to trip him up instead discussing his ideas.
The Democrats' response? Nancy Pelosi (bless her heart) called it "snake oil." Women members of the Party did worse. I suspect that the Lord sent an evil spirit that whispered to the Democrat women to wear white. Supposedly it was to remind everyone of the Suffragettes. Their problem is that there is not a single jurisdiction in the Country that bars women from voting, so the gesture was at best meaningless. What it reminded us was the KKK. All those women needed were the dunce caps.
Thursday, March 2, 2017
Wednesday, March 1, 2017
Europe: What is target 2?
Target 2 is a financing mechanism that has been corrupted into a debt generating mechanism. By this mechanism, the debts of Southern Mediterranean countries have been transferred to German banks.
Let's say an Italian company wants to buy something in Germany. The Italian company borrows the money from the Italian Central Bank, which then borrows the money from the ECB. The ECB then borrows the money from German banks, where the debt accumulates. So, it becomes a mech to transfer money from Germany to other countries while promoting the sale of German goods.
Spain has borrowed E328B, Italy E368B and Greece and Portugal each about E150B. But, this will be repaid, no? Not a chance.
Let's say an Italian company wants to buy something in Germany. The Italian company borrows the money from the Italian Central Bank, which then borrows the money from the ECB. The ECB then borrows the money from German banks, where the debt accumulates. So, it becomes a mech to transfer money from Germany to other countries while promoting the sale of German goods.
Spain has borrowed E328B, Italy E368B and Greece and Portugal each about E150B. But, this will be repaid, no? Not a chance.
Monday, February 27, 2017
Cancer immunotherapy advances.
Inovio’s SynCon® WT1 Cancer Antigen Breaks Tolerance, Highlights Potential for Universal Cancer Immunotherapy
Feb 27, 2017
SynCon WT1 and PSMA antigens join hTERT in INO-5401, Inovio’s cancer product planned for immuno-oncology combination study
Results of these pre-clinical studies appear in the online edition of Molecular Therapy in a paper entitled, “A novel DNA vaccine platform enhances neo-antigen-like T-cell responses against WT1 to break tolerance and induce anti-tumor immunity,” authored by Inovio and its collaborators at The Wistar Institute .
Study results revealed that while mice did not mount an immune response to native mouse WT1 antigens, mice immunized with Inovio’s SynCon WT1 antigen broke tolerance and generated robust neo-antigen-like T cells. Furthermore, the immunized mice exhibited smaller tumors and prolonged survival in a tumor challenge study. SynCon WT1 DNA vaccination also broke tolerance and generated neo-antigen-like T cell immune responses in Rhesus monkeys, a species whose immune system closely resembles that of humans. Inovio’s ability to overcome the immune system’s usual tolerance of WT1 antigen suggests the potential of its SynCon WT1 antigen to tackle any WT1-expressing cancer in humans, which include pancreatic, brain, lung, thyroid, breast, testicular, ovarian, and melanoma.
Dr. J. Joseph Kim , Inovio's President and CEO, said, "Our SynCon antigens’ ability to overcome the immune system’s inability to recognize tumor self-antigens is unique and powerful. While we systematically and synthetically mimic the body’s natural process of creating tumor neo-antigens, which possess differentiated but individualized genetic sequences that may then induce an immune response, our ability to break tolerance with broadly prevalent antigens makes our approach more universal across populations. We are pleased to again show such results with an important cancer antigen – in this case, WT1 – and continue to add to our array of promising universal cancer antigens in Inovio’s product development strategy.
“To expand on our capabilities and strategy, the power of our differentiated antigens dovetails with our ability to turn cancer tumors from cold to hot by creating a significant presence of antigen-specific CD8+ killer T cells in a target lesion or tumor microenvironment, which we have shown via biopsies in two human studies. These are critical outcomes: although checkpoint inhibitors have raised the bar for treating cancers by neutralizing cancer cells’ inherent ability to switch off T cells that are hunting them, they do not actually generate the antigen-specific killer T cells required to destroy cancer cells. We believe our DNA-based SynCon immunotherapies are the missing link to take immuno-oncology to the next level.”
“With these accomplishments we could not be more enthusiastic about two immuno-oncology combination human studies to start in the first half of 2017. MedImmune will combine INO-3112 (also named MEDI0457) with their checkpoint inhibitor molecule in an upcoming clinical study. Inovio is also planning to conduct a combination study for INO-5401 with a checkpoint inhibitor in cancer patients. We previously noted that INO-5401 will include our hTERT SynCon antigen. I am pleased to say that INO-5401 will also include our SynCon antigens for WT1 and PSMA. We believe this product has the potential to be a very powerful universal cancer immunotherapy in combination with different checkpoint inhibitors.”
Inovio’s synthetically designed antigens use a consensus of human and multiple animal genetic sequences for the same antigen to create a differentiated SynCon® antigen that can be more readily recognized as “foreign” by immune sentries in the patients. This recognition may help overcome the immune system’s tolerance of tumor cells displaying the native or self-antigens generated by the body. Once a significant antigen-specific T cell response is activated, these T cells may then also seek throughout the body and destroy cancer cells expressing the pre-existing natural or native tumor antigens.
There are multiple lines of evidence pointing to the potential of INO-5401 in immuno-oncology. Inovio previously reported preclinical data indicating the ability of its PSMA and hTERT tumor-associated SynCon antigens to generate significant antigen-specific killer T cell responses. Inovio is also running an ongoing phase I study of its SynCon hTERT antigen (INO-1400) to assess safety and immunogenicity in over fifty patients with at least one of nine different hTERT-expressing cancers. Our SynCon PSMA antigen is one of two components (along with SynCon PSA) making up INO-5150, which is currently in a phase I study of sixty biochemical-relapse prostate cancer patients. Interim immune responses and safety data from both INO-1400 and INO-5150 studies will be presented at cancer conferences in 2017.
Importantly, Inovio has already reported human data characterizing the activation of significant antigen-specific CD8+ killer T cells in patients and their infiltration into lesions and tumors displaying target antigens. These studies of HPV-related precancer (VGX-3100) and cancer (INO-3112) showed a significant presence of activated T cells based on pre and post immunization biopsies. In a controlled phase 2b study for VGX-3100, Inovio also showed statistically significant efficacy in regressing HPV-related cervical dysplasia.
Sunday, February 26, 2017
Stem cells can affect heart repair.
The use of stem cells to repair tissue has been a long sought after goal in medicine. This is especially true, since stem cells can be produced that do not cause immune rejection (see details of a company called ISCO). Now, British scientists have figured out how to repair heart cells damaged by heart attacks or heart failure:
http://www.express.co.uk/life-style/health/772124/heart-condition-failure-stem-cells-trial-repair-tissue
This is in a British paper so it has sidetracks to almost everything.
http://www.express.co.uk/life-style/health/772124/heart-condition-failure-stem-cells-trial-repair-tissue
This is in a British paper so it has sidetracks to almost everything.
Saturday, February 25, 2017
Gold: Is this it now?
I know you have heard this song before: gold is about to break out. When? In 2017. Within 90 days.
How come I say this?
I rely on the report of Andrew Maguire, a legendary whistleblower.
http://kingworldnews.com/andrew-maguire-death-knell-of-central-bank-manipulation-to-send-gold-silver-skyrocketing-in-2017/
According to Andrew M the manipulators now face a ratio of paper contracts to gold delivered of 100 to 1 and there is simply no more gold available to be delivered. So, if the manipulators tried to reduce the gold price by writing a bunch of contracts, they will not be able to deliver unless they buy gold. At this point, the physical Market becomes the controlling factor to set the gold price. Sure enough, this last Friday gold moved past 1,250/oz.
There were some interesting anomalies as well this last week. While gold shorts remained at a decreased level, silver shorts had increased along with shorts in oil:
http://kingworldnews.com/danger-silver-crude-oil-warning-as-gold-bull-market-nears-massive-breakout/
Furthermore, while the price of silver went up nearly 18 cents/oz, silver miners took a tumble. I have no explanation for the anomalies. Nor can I forecast when the breakout in PM prices will occur.
How come I say this?
I rely on the report of Andrew Maguire, a legendary whistleblower.
http://kingworldnews.com/andrew-maguire-death-knell-of-central-bank-manipulation-to-send-gold-silver-skyrocketing-in-2017/
According to Andrew M the manipulators now face a ratio of paper contracts to gold delivered of 100 to 1 and there is simply no more gold available to be delivered. So, if the manipulators tried to reduce the gold price by writing a bunch of contracts, they will not be able to deliver unless they buy gold. At this point, the physical Market becomes the controlling factor to set the gold price. Sure enough, this last Friday gold moved past 1,250/oz.
There were some interesting anomalies as well this last week. While gold shorts remained at a decreased level, silver shorts had increased along with shorts in oil:
http://kingworldnews.com/danger-silver-crude-oil-warning-as-gold-bull-market-nears-massive-breakout/
Furthermore, while the price of silver went up nearly 18 cents/oz, silver miners took a tumble. I have no explanation for the anomalies. Nor can I forecast when the breakout in PM prices will occur.
Vietnamese soup.
Rush Limbaugh mused as to why Liberals demonstrate and Conservatives do not. He concluded that Liberal demonstrations are driven by hate and Conservatives do not hate. Well, there is an exception to that: we do hate the Press. Supercilious, sanctimonious fakers they are, anti-American, anti-white and anti-Christian. But, that is why we DESPISE them. Our hatred for Liberal members of the Press is due to their complicity in extinguishing freedom in Vietnam. That we will never forgive them. After 50,000 American casualties and a lot more Vietnamese that perished at the hands of the Communists and later in the sea, there is no forgiveness for the Liberal betrayal of the people of Vietnam and America's lost soldiers.
Was Vietnam a total loss? No. We got some wonderful people that came to us as refugees and most of them did not join the Democrats who sounded to them suspiciously like the Viet Cong that tormented them. Oh and there was another thing we gained: the knowledge of how to make Pho soup.
Pronunciation of PHO varies. One lady told me it is pronounced as in 'foe.' Another lady told me that it is "phah" that I need to describe so you can fully appreciate. Imagine that you are 10 years old and are just starting to drop the F-bomb. Halfway through, your Mother looks at you and the rest of the word dies unsaid. I prefer the foe pronunciation.
Pho is basically a spiced broth served with rice noodles and chopped (uncooked) vegetables. The broth is made with beef knuckle bones that are simmered for 5-6 hours, so fresh pho is consumed for breakfast (or so I am told). We make the pho in a pressure cooker that reduces the cooking time to 75 minutes, but preparation takes some doing anyway.
Ingredients for the broth.
About 2 lbs beef bones or pork bones with some meat on them
2 medium yellow onions
about an inch and a half ginger
2 TBSP canola oil
3 5 -star anise pods
6 whole cloves
1/2 tsp ground coriander
1 tsp fennel seed
1 cinnamon stick
Preparation of the broth.
1. Slice the onions and the ginger, oil a pan and broil till onions blacken
2. Add to Instapot along with the spices and 12 cups water
3. Pressure cook for 75 minutes.
4. Remove beef or pork pieces and save the meat.
5. Strain the broth and discard everything but the broth.
Serving.
1. Prepare rice noodles according to instructions and use some in each bowl. Pho bowls look big and deep.
2. Chop up or slice some vegetables to add (Can use green peppers, cabbage and green onions).
3. Add 1/4 lime and some cilantro.
4. Add some hot sauce or siraccha to each bowl as preferred.
Original recipe calls foe adding bean sprouts.
Source.
@kitchn
Was Vietnam a total loss? No. We got some wonderful people that came to us as refugees and most of them did not join the Democrats who sounded to them suspiciously like the Viet Cong that tormented them. Oh and there was another thing we gained: the knowledge of how to make Pho soup.
Pronunciation of PHO varies. One lady told me it is pronounced as in 'foe.' Another lady told me that it is "phah" that I need to describe so you can fully appreciate. Imagine that you are 10 years old and are just starting to drop the F-bomb. Halfway through, your Mother looks at you and the rest of the word dies unsaid. I prefer the foe pronunciation.
Pho is basically a spiced broth served with rice noodles and chopped (uncooked) vegetables. The broth is made with beef knuckle bones that are simmered for 5-6 hours, so fresh pho is consumed for breakfast (or so I am told). We make the pho in a pressure cooker that reduces the cooking time to 75 minutes, but preparation takes some doing anyway.
Ingredients for the broth.
About 2 lbs beef bones or pork bones with some meat on them
2 medium yellow onions
about an inch and a half ginger
2 TBSP canola oil
3 5 -star anise pods
6 whole cloves
1/2 tsp ground coriander
1 tsp fennel seed
1 cinnamon stick
Preparation of the broth.
1. Slice the onions and the ginger, oil a pan and broil till onions blacken
2. Add to Instapot along with the spices and 12 cups water
3. Pressure cook for 75 minutes.
4. Remove beef or pork pieces and save the meat.
5. Strain the broth and discard everything but the broth.
Serving.
1. Prepare rice noodles according to instructions and use some in each bowl. Pho bowls look big and deep.
2. Chop up or slice some vegetables to add (Can use green peppers, cabbage and green onions).
3. Add 1/4 lime and some cilantro.
4. Add some hot sauce or siraccha to each bowl as preferred.
Original recipe calls foe adding bean sprouts.
Source.
@kitchn
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